Independent Schools of St. Louis, a non-profit professional association established in 1972, includes 45 independently governed elementary and secondary schools throughout the metropolitan St. Louis region. Full Membership schools are independent schools that hold full membership with the Independent Schools of the Central States (ISACS) or AdvancED or are otherwise approved by the ISSL Board of Trustees.
Schools that are members of Independent Schools of St. Louis provide a complete range of educational opportunities for students in pre-kindergarten through grade 12. They include schools that focus on traditional models of excellence in education as well as special needs schools, which specialize in areas that include learning differences or emotional and behavioral problems. A number of schools are religiously affiliated.